Search results for " iontophoresis"

showing 3 items of 3 documents

Human buccal mucosa as an innovative site of drug delivery.

2009

The authors review the ultra-structural aspects and permeability features of normal human oral mucosa, after having recently tested and used it as a new site of systemic drug delivery. The pertinent scientific literature from 1975 through 2009 has been analysed and discussed. Buccal epithelium is a relatively permeable, robust non-keratinized tissue and blood vessels drain directly into the jugular vein; due to its particular features, it has been of increasing interest to researchers as an alternative site of drug administration. The review describes the structure and function of the buccal mucosa, the rationale for transbuccal drug delivery and the main transmucosal drug delivery systems.…

Drugmedia_common.quotation_subjectDentistryAdministration OralPharmacologyBuccal mucosaRoute of administrationDrug Delivery SystemsOral administrationSettore MED/28 - Malattie OdontostomatologicheDrug DiscoverymedicineHumansOral mucosamedia_commonPharmacologybusiness.industryCell MembraneMouth MucosaAdministration BuccalBuccal administrationStructure and functionDrug delivery human oral mucosa transbuccal permeation reconstituted human oral epithelium iontophoresismedicine.anatomical_structurePharmaceutical PreparationsSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliverybusinessCurrent pharmaceutical design
researchProduct

Physical methods to promote drug delivery on mucosal tissues of the oral cavity.

2013

Introduction: The successful of drug delivery through the mucosal tissue of the oral cavity represents a current challenge as well as a great future perspective. The need for more rapid onset of action and improved absorption of medications has resulted in great development of drug delivery technologies that use physical methods to overcome the barrier properties of oral mucosae. Areas covered: This review discusses the various physical techniques which have been, and are being, explored to sustain drug delivery in the oral cavity. In particular, supersaturation, eutectic formation, iontophoresis, electroporation, sonophoresis, laser radiation, photomechanical waves, and needleless injectio…

Drugmedicine.medical_specialtymedia_common.quotation_subjectChemistry PharmaceuticalPharmaceutical ScienceBiological AvailabilityPharmacologyOral cavityPermeabilityAbsorptionDrug Delivery SystemsmedicineAnimalsHumansIntensive care medicinemedia_commonFuture perspectiveIontophoresisMucosal permeabilityMouth MucosaIontophoresisSonophoresisElectroporation eutectic systems iontophoresis jet injection photodynamic therapy photomechanical waves sonophoresis supersaturated systemsPharmaceutical PreparationsSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoRapid onsetDrug deliveryHalf-LifeExpert opinion on drug delivery
researchProduct

Physical Methods for Enhancing Oral Mucosal Delivery: Sonophoresis, Iontophoresis and Electroporation

2015

The need for more rapid onset of action and improved absorption of medications has resulted in great development of drug delivery technologies. Transmucosal drug delivery offers a convenient route of administration for a variety of clinical indications. Unfortunately, the wide variability in structure of the oral mucosal tissues could constitute a key factor in drug penetration and absorption. To circumvent this obstacle and to increase the drug flux through the mucosal membranes, different approaches to permeation enhancement are used. This chapter describes the most significant aspects of the physical techniques widely used such as sonophoresis, iontophoresis, and electroporation. These p…

Sonophoresis iontophoresis electromigration electroosmosis electroporation physical permeation enhancement oral mucosal deliveryIontophoresisSettore CHIM/09 - Farmaceutico Tecnologico Applicativobusiness.industryElectroporationRapid onsetDrug deliveryMedicineAbsorption (skin)PharmacologybusinessSonophoresis
researchProduct